| REACH support |
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| Toxicological data processing |
| Summarise existing information |
| Consider adequacy, key studies & data gaps |
| Generate data/testing plan |
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| Toxicological endpoints (quantitative evaluation) |
| No Observed Adverse Effect Level/Concentration (NOAEL, NOAEC) |
| Benchmark Dose (BMD) |
| Assessment Factors (AF) |
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| Toxicological data interpretation (qualitative evaluation) |
| Mechanism of Action (MoA) |
| Relevance to man (treshold/non-treshold) |
| Weight of Evidence (WoE) |
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| Toxicological data comparison (predictive evaluation) |
| Analogues searching |
| Read-Across evaluation |
| (Quantitative) Structure-Activity Relationships (QSAR) |
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| Chemical Safety Assessment/Report (CSA/CSR) |
| Hazard & Effects assessment: Derived No Effect Level (DNEL)/ Predicted No Effect Concentration (PNEC) |
| Exposure assessment: Predicted Environmental Concentration (PEC) |
| Risk characterisation and Classification |
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| REACH in brief (pdf file) |
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Reflector Consulting provides services in chemical pharmaceutical and biomedical Research & Development. Areas of expertise are TOXICOLOGY program design, study monitoring and regulatory documentation on the one hand, and QUALITY aspects, including compliance and efficiency improvement on the other hand.